Tuesday, January 31, 2012

Islamist sect kills 5 people in northeast Nigeria (AP)

MAIDUGURI, Nigeria ? Police say suspected Islamic insurgents have killed five people in attacks on security targets in Nigeria's restive northeast.

The Borno state police spokesman said Tuesday that Boko Haram gunmen attacked an air force barracks, a police station and an army checkpoint Monday, about 90 miles (150 kilometers) north of the sect's stronghold in the city of Maiduguri.

Samuel Tizhe said the dead include a soldier, two policemen and two civilians.

An army official said a soldier was shot in the arm during the checkpoint attack.

Boko Haram claimed responsibility for a series of attacks that left at least 185 dead in northern Nigeria's largest city, Kano, earlier this month.

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/ap/20120131/ap_on_re_af/af_nigeria_violence

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In lab, Pannexin1 restores tight binding of cells that is lost in cancer

Monday, January 30, 2012

First there is the tumor and then there's the horrible question of whether the cancerous cells will spread. Scientists increasingly believe that the structural properties of the tumor itself, such as how tightly the tumor cells are packed together, play a decisive role in the progression of the disease. In a new study, researchers show that the protein Pannexin1, known to have tumor-suppressive properties, plays an important role in keeping the cells within a tissue closely packed together, an effect that may be lost with cancer.

"In healthy tissues, the recently discovered protein Pannexin1 may be playing an important role in upholding the mechanical integrity of the tissue," said first author and Brown University M.D./Ph.D. student Brian Bao. "When we develop cancer, we lose Pannexin1 and we lose this integrity."

The results appeared in advance online in the Journal of Biological Chemistry on Jan. 20.

To conduct their research, the group at Brown University and the University of British Columbia employed a "3-D Petri dish" technology that allows investigators to watch closely how cells interact with each other, without scientists having to worry about additional interactions with surrounding scaffolding or the culture plate itself. How readily the cells form large multicellular structures therefore reflects their interactions with each other, not their in vitro surroundings.

Bao's advisor, Jeffrey Morgan, associate professor of medical science, developed the 3-D Petri dish technology. Morgan is the paper's senior author.

Cancer cells converge

Starting with rat "C6" glioma (brain tumor) cells that do not express Pannexin1, the researchers left some unaltered and engineered others to express Pannexin1. After putting the different cells into the 3-D Petri dishes and watching them interact for 24 hours, they saw that the Pannexin1 cells were able to form large multicellular tissues much faster and more tightly than the unaltered cancer cells.

To confirm that Pannexin1 was indeed causing these changes, Bao and his colleagues treated their samples with the drugs Probenecid and Carbenoxolone, which are well known inhibitors of Pannexin1. They saw that sure enough, the drugs negated Pannexin1's accelerating effect.

Then the team was ready to achieve the the study's main aim, Bao said, namely to determine how Pannexin1 was able to drive these cells to clump together faster and tighter. They found that Pannexin1 sets off a chain reaction involving the energy-carrying molecule ATP and specific receptors for it.

When all experiments were done, Bao, Morgan, and their collaborators had found that as soon as the cells touched each other, Pannexin1 channels were stimulated to open and release ATP. The ATP then bound to cell surface receptors, kicking off intracellular calcium waves that ultimately remodeled the network of a structural protein called actin. This remodeling increases the forces between the cells, driving them to bind together more tightly.

Figuring out that sequence, and Pannexin1's role in it, is perhaps the study's biggest contribution to cancer research, Bao said.

"Using their single-cell systems, others have been able to carefully study individual pieces of this cascade," he said. "We came from a different perspective. Because the strength of our assay is that we can look at gross multicellular behavior in 3-D, we could ask, 'Does this actually manifest into something tangible on the multicellular level?'"

Having gained this understanding of Pannexin1's role in the mechanics of tumors, Bao is now engaged in research to answer the obvious next questions: Does Pannexin1 affect the tumor's ability to spread and invade? When cancerous cells regain Pannexin1 expression, are they less likely to spread and leave the tumor?

###

Brown University: http://www.brown.edu/Administration/News_Bureau

Thanks to Brown University for this article.

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Source: http://www.labspaces.net/117181/In_lab__Pannexin__restores_tight_binding_of_cells_that_is_lost_in_cancer

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Monday, January 30, 2012

Winter cold snap kills 36 in eastern Europe

A couple walks on a snow covered road near the Lake of Eymir, Ankara, Turkey, on Sunday, Jan. 29, 2012. Winter temperatures and recent snowfall has partially paralyzed life in Turkey. (AP Photo/Selcan Hacaoglu)

A couple walks on a snow covered road near the Lake of Eymir, Ankara, Turkey, on Sunday, Jan. 29, 2012. Winter temperatures and recent snowfall has partially paralyzed life in Turkey. (AP Photo/Selcan Hacaoglu)

Coots fight for a piece of bread on the frozen Lake of Eymir, near Ankara, Turkey, on Sunday, Jan. 29, 2012. Winter temperatures and recent snowfall has partially paralyzed life in Turkey. (AP Photo/Selcan Hacaoglu)

Coots run for a piece of bread on the frozen Lake of Eymir, near Ankara, Turkey, on Sunday, Jan. 29, 2012. Winter temperatures and recent snowfall has partially paralyzed life in Turkey. (AP Photo/Selcan Hacaoglu)

(AP) ? A severe and snowy cold snap across central and eastern Europe has left at least 36 people dead, cut off power to towns, and snarled traffic. Officials are responding with measures ranging from opening shelters to dispensing hot tea, with particular concern for the homeless and elderly.

This part of Europe is not unused to cold, but the current freeze, which spread to most of the region last week, came after a period of relatively mild weather. Many were shocked when temperatures in some parts plunged Monday to minus 20 Celsius (minus 4 Fahrenheit).

"Just as we thought we could get away with a spring-like winter ..." lamented Jelena Savic, 43, from the Serbian capital of Belgrade, her head wrapped in a shawl with only eyes uncovered. "I'm freezing. It's hard to get used to it so suddenly."

Officials have appealed to people to stay indoors and be careful. Police searched for the homeless to make sure they didn't freeze to death. In some places, heaters will be set up at bus stations.

Still, 18 people, most of them homeless, died in Ukraine from hypothermia and nearly 500 people sought medical help for frostbite and hypothermia in just three days last week, the Emergency Situations Ministry said.

Temperatures in parts of Ukraine fell to minus 16 C (3 F) during the day and minus 23 C (minus 10 F) in the night. Authorities opened 1,500 shelters to provide food and heat and closed schools and nurseries. More than 17,000 people have sought help in such shelters in the past three days, authorities said.

In Poland, at least 10 people froze to death as the cold reached minus 26 C (minus 15 F) on Monday.

Malgorzata Wozniak, a spokeswoman for Poland's Interior Ministry, told The Associated Press that elderly people and the homeless were among the dead. Police were checking unheated empty buildings for homeless people they could take to shelters.

Warsaw city authorities decided to place more than 40 heaters in the busiest city transport stops to help waiting passengers keep warm.

City authorities in the Czech capital of Prague set up tents for an estimated 3,000 homeless people. Freezing temperatures also damaged train tracks, slowing railway traffic.

In central Serbia, three people died and two more were missing, while 14 municipalities were operating under emergency decrees. Efforts to clear roads blocked by snow were hampered by strong winds and dozens of towns faced power outages.

Police said one woman froze to death in a snowstorm in a central Serbian village, while two elderly men were found dead, one in the snow outside his home. Further south, emergency crews are searching for two men in their 70s who are feared dead.

"We are getting some 'real' winter this week," Croatian meteorologist Zoran Vakula said.

In Bulgaria, a 57-year-old man froze to death in a northwestern village and emergency decrees were declared in 25 of the country's 28 districts. In the capital of Sofia, authorities handed out hot tea and placed homeless people in emergency shelters.

Strong winds also closed down Bulgaria's main Black Sea port of Varna, while part of a major highway leading to Bulgaria and Greece from Turkey was closed after a heavy snowfall. Nearly 200 Turkish Airlines flights to and from Istanbul's Ataturk Airport were canceled, and a city sports hall was turned to a temporary shelter for some 350 homeless people.

The temperature in Turkey's province of Kars, which borders Armenia, dropped to minus 25 C on Sunday night.

The situation was similar in Romania, where reports said four people have died because of freezing weather. There, authorities sent prison inmates to shovel snow and unblock paths leading to a shelter with some 300 stray dogs and puppies.

Weather forecasts say the cold snap will continue through the week.

_____

Associated Press writers across the region contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-01-30-EU-Europe-Weather/id-5ad7e01a4a3d4ba3aef4a7e2ef6420e6

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Source: http://www.cendresetsang-lefilm.com/uncategorized/investing-strategy-covered-call-things-you-need-to-know

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Sunday, January 29, 2012

Tributes to Paterno highlight influence of wife (AP)

STATE COLLEGE, Pa. ? For decades, Joe Paterno was the public face of Penn State. For almost as long, his near-constant companion, wife Sue, seemingly wielded as much influence.

As tributes flowed this week for the late Hall of Fame coach, the extent of Sue Paterno's sway on her husband, the football program and the university became obvious, for those watching in or outside of Happy Valley.

She served as a host to potential recruits at the family home, a tutor to players, a counselor to concerned parents who entrusted their football-playing sons to her husband, and a prodigious fundraiser for the university and charitable organizations.

While a bronze statue outside Beaver Stadium memorializes the legacy of the winningest coach in major college football, it was Sue Paterno who was her husband's rock.

"For my dad, he never doubted my mother," their son Jay said at Thursday's memorial service for his father. "My mother had it all and continues to have it all. He could do his job and we could share him with Penn State because he knew my mother was in complete command on the home front."

Through the recent months of scandal that engulfed the university and a week's worth of private and public memorials for Penn State's longtime coach, other lasting images of Sue Paterno have emerged:

_She showed her spunk by coming to her husband's defense with a quick callback to a trustee after Joe Paterno was unceremoniously fired via a phone call. "After 61 years he deserved better," Sue Paterno said according to The Washington Post. Then, she hung up.

_A short time after being dismissed, she stood arm in arm with her husband as they stepped outside their modest State College home and greeted hundreds of well-wishers.

_And at the end of an emotional week in State College, Sue Paterno appeared composed, only occasionally fighting back tears, with her arms around some of her grandchildren as about 12,000 people gathered for public memorial. She rose from her seat and joined in a standing ovation as speakers defended his legacy against criticism that he failed to do more when told about an alleged child sexual assault involving one of his former assistants.

The Paternos were about as close to royalty as you can get in Happy Valley ? a modest first family of college football.

"They went everywhere together," former quarterback Daryll Clark said this week. "They were one and one."

Joe Paterno died Sunday at age 85, less than three months after being diagnosed with lung cancer.

"Joe Paterno indeed had an indomitable will with one exception: when his will ran counter to that of his wife and my mother," Jay Paterno said in a light moment from the memorial service for the man who became lovingly known around town as "JoePa."

Save for a few moments, 71-year-old Sue Paterno looked composed for a widow who just lost her husband under already emotional circumstances. Their family announced Paterno had been diagnosed with cancer just 10 days after he was ousted on Nov. 9 as Penn State coach following 46 seasons.

Sue and Joe Paterno were side by side on the family's front walk the night of the dismissal as he tried to console fans upset that he had been fired in the aftermath of child sex abuse charges against retired assistant Jerry Sandusky.

She joined the rest of the crowd at the memorial service giving Phil Knight a standing ovation after the Nike founder and CEO gave the most impassioned defense yet of her husband's legacy in the wake of the firing.

Appearing to nearly tear up at times, she otherwise looked poised during the emotional service that included several video tributes to Paterno, who amassed 409 victories.

Despite their recognition, they led lives similar to others who worked at Penn State. They raised five children in a ranch home next to a local park. There's no fence lining the front yard and no gates guarding the driveway.

The family's phone number is listed in the phone book. It was a way, Sue Paterno has said, for families of players to reach them in an emergency.

Besides tutoring players and helping to counsel players' parents, Sue Paterno was a prodigious fundraiser for the university library that bears the family's name ? it was, after all, where Joe and Sue met, when he was an assistant coach and she a freshman at the school.

He had a degree in English literature from Brown. She was an English student.

Outside of football, they rarely spent a moment apart.

"Besides Joe coaching and being at the football building, those two were inseparable," Clark said. He said the Paternos treated him as if he were one of their own children.

Sue Paterno baked spreads of cookies and desserts when the family hosted recruiting visits. Current and former players still rave about them.

At the memorial service, former receiver Kenny Jackson recounted a conversation Sue Paterno had with his family while he was being recruited. She reinforced the themes Joe Paterno promoted in his "grand experiment" of placing as much emphasis on academics as athletics.

"Sue only promised two things: the first, Kenny will go to class; second, he will get a quality education," Jackson said. "That's all she said. She never talked about anything else but my education. So I thank you Sue. ... You always made sure that was the first priority."

And she's responsible for perhaps one of the most lasting game-day memories of Joe Paterno.

Back in the late `60s, Sue Paterno suggested he raise the cuffs on his pants so mud wouldn't get on his wool slacks while coaching. It wasn't as much a concern when JoePa switched to his trademark khakis ? but Sue Paterno said her husband kept rolling them up anyway as a superstition.

"People don't realize how much she's done for this place," Joe Paterno said in an interview with The Associated Press in 2009. "I've said many times that they won't have any problems replacing me, but if they can find a coach's wife like Sue, they'll hit the jackpot."

The Paternos became renowned in the community for their generosity. They championed Special Olympics and THON, the Penn State student-organized dance marathon charity that raises millions of dollars annually for childhood cancer research and treatment.

They've contributed more than $4 million to the university during his tenure, including $3.5 million in 1998 to endow faculty positions and scholarships, and support two building projects.

Minus endorsements outside his university contract, Paterno made just more than $1 million a year, a relative bargain for a coach with two national championships.

Three years ago, the Paternos pledged $1 million to help build a new wing at Mount Nittany Medical Center, the State College hospital where Joe Paterno died Sunday.

There were no flowers or balloons in the room, Scott Paterno said ? not Joe's style. He suspected his mother had them redirected to other patients in the hospital.

Joe Paterno died less than three months after the emergence of the stunning scandal that led to his dismissal. University trustees ousted him Nov. 9, four days after charges were first filed against Sandusky. He is out on bail and awaiting trial after denying the allegations.

Paterno was a witness before a state grand jury investigating Sandusky, and authorities have said he was not a target of the probe. Paterno had testified he had relayed a 2002 abuse allegation passed on by a graduate assistant to campus superiors, fulfilling his legal obligation.

School trustees in recent weeks have cited, in part, Paterno's failure to fulfill a moral duty to tell police outside the university as a reason for his dismissal.

A tenure of more than six decades with the football program, including 15 years as an assistant before being promoted to head coach, had come to an end in early November. The cancer diagnosis came several days later.

Sue Paterno was constantly at her husband's side, Scott Paterno said.

One of Scott Paterno's lasting memories from the last few months, as his father fought illness, was the picture of his parents sitting at a table at home, surrounded by their children and 17 grandchildren on Dec. 21 as they celebrated his 85th birthday.

"She's got his hand on him and they're sitting there looking around and they've got their smiles on their faces," Scott Paterno said. "Just two of the most happy and contented people looking around the house, looking at their children and their grandchildren and it was like `You know, this is what our life is, this is what we built.'"

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20120128/ap_on_sp_co_ne/fbc_penn_state_the_paternos

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US women's soccer team qualifies for Olympics (AP)

VANCOUVER, British Columbia ? The final goal in the game that put the U.S. women's soccer team into the Olympics was scored by Alex Morgan, the super-sub who made her name at last year's World Cup.

That's the same Alex Morgan who wasn't a sub at all in the Americans' previous game, leading to an interesting moment in a meeting with coach Pia Sundhage.

The formality is that the U.S. beat Costa Rica 3-0 Friday night to earn a ticket to London. The game was quite a bit more suspenseful than expected, with the Americans overcoming some early sloppiness and waiting until deep into the second half to put the game away.

The real fun now begins over the next six months as Sundhage figures out how best to use the best, deepest roster of women soccer players in the world. For instance, the newest hot-off-the-presses talent is Sidney Leroux, who got the call instead of Morgan in the second half of the big win over Mexico three days earlier.

"I asked her how she felt when Sidney Leroux came in the game and she didn't," Sundhage said. "I wanted an honest answer. She said `I don't think you want that answer.' Great. That tells a little about how badly she wants to play."

Morgan felt she got her point across.

"We both laughed," Morgan said. "And she said `That's all I need to know.' ... But that's the great thing with Pia. She lets you feel you can be honest with her. She lets you feel very comfortable around her."

Morgan's goal in the 89th minute made the score 34-0 ? the margin by which the Americans have outscored their opponents at the CONCACAF qualifying tournament. The only one that wasn't as lopsided as the score was Friday's London-or-bust semifinal.

"There were moments where I think Costa Rica were outplaying us, and it just shows you how important it was to all of us," forward Abby Wambach said. "Nobody wanted to make that mistake. And luckily we didn't."

Tobin Heath scored in the 16th minute to give U.S. all the offense it needed, and Carli Lloyd (72nd) and Morgan (89th) provided the insurance.

But the top-ranked Americans were certainly not as crisp as they were when they were drawing criticism for running up the score. Bad passes led to giveaways in the first half, forcing goalkeeper Hope Solo to work harder than she has all tournament.

Then again, so much was on the line that some jitters were understandable.

"We know that sometimes under big game circumstances players can get a little tight," Wambach said. "And you've just kind of got to deal with it. ... It was almost as if we scored that goal and nobody wanted to get stuck into a tackle. We were kind of playing a little bit soft, and we fixed that in the second half."

Costa Rica is ranked No. 41 in the world, has never qualified for an Olympics or a World Cup and has never scored on the U.S. in eight meetings. Las Ticas proved to be scrappy opponents, however, occasionally frustrating the Americans with physical play and just missing on two solid scoring chances in the first half in the London-or-bust match. As the possibility of an upset lingered deep into the second half, the plucky team in red gained the rousing support of the Canadian fans at BC Place.

"We put together three great games in group play," said Solo, who played despite a slightly pulled right quadriceps that had been bothering her all week. "You can't play four, five, six. Not every team is going to play perfectly every single game, but we got the job done."

The U.S. will be the two-time defending champions in London, having taken gold in Athens in 2004 and in Beijing in 2008. It will be the third straight Olympics in which the Americans will be trying to make amends for World Cup disappointment from the previous year. They finished second at last year's World Cup in Germany, losing to Japan in the final.

The victory also puts the Americans into the tournament final Sunday, a bragging-rights-only game against Canada, a 3-1 winner over Mexico in the second semifinal.

Sundhage's team arrived in Canada with a bit of apprehension. The Americans, having become somewhat complacent from years of uncontested success in the region, were stunned in a World Cup qualifier by host Mexico in November 2010, forcing them into a home-and-away playoff with Italy just to get for the World Cup. Also, the format for Olympic qualifying is such that everything hinges on one game ? the do-or-die semifinals ? regardless of how a team performs in the rest of the tournament.

Determined to take nothing for granted, the Americans had been full throttle for every game. They set a U.S. team record for goals in a game in a 14-0 win over the Dominican Republic, then nearly matched the feat in a 13-0 rout of Guatemala. Then came a 4-0 win in the much-anticipated rematch with Mexico to set up the semifinal against Costa Rica.

And even though the vital game didn't go quite as planned, the outcome was all that mattered.

"We," Sundhage said, smiling, "are going to London."

__

Joseph White can be reached at http://twitter.com/JGWhiteAP

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20120128/ap_on_sp_ol/oly_soc_us_qualifies

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Saturday, January 28, 2012

Justice unit to probe mortgage-backed securities (AP)

WASHINGTON ? Federal and state law enforcement officials announced Friday they have launched a fraud-fighting unit, starting with 55 prosecutors and investigators, to root out wrongdoing in the market for residential mortgage-backed securities.

Attorney General Eric Holder told a news conference the team will benefit from existing probes and disclosed that investigators have issued civil subpoenas to 11 financial institutions in recent days, with the prospect that "more will follow." He said bringing full enforcement resources to bear will help expose abuses and hold violators accountable.

Residential mortgage-backed securities are the huge investment packages of what turned out to be near-worthless mortgages that bankrupted many investors and contributed to the nation's financial crisis.

Appearing with Holder, New York Attorney General Eric Schneiderman, a co-chair of the initiative, held out the prospect that information sharing between federal and state investigators will produce more far-reaching results. He pointed out that New York state securities law is more flexible than federal securities law, which can make it easier to assemble cases.

As for those who engaged in misconduct in the financial industry, "we know what they did, they know what they did and, we know they know we know what they did," said Schneiderman.

"Mortgage products were in many ways ground zero for the financial crisis," said Robert Khuzami, director of the enforcement division at the U.S. Securities and Exchange Commission.

The collapse in value of mortgage-backed securities resulted in unprecedented losses, and "all of us" in law enforcement are dedicated to holding accountable financial institutions that lied and cheated and misled investors, said Khuzami.

President Barack Obama disclosed the new effort in his State of the Union address Tuesday night.

Source: http://us.rd.yahoo.com/dailynews/rss/personalfinance/*http%3A//news.yahoo.com/s/ap/20120127/ap_on_go_ca_st_pe/us_financial_probers

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